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  • Canadian Health News

  • Activating mutations of the calcium-sensing receptor in primary hypoparathyroidism: Structure and function of the CaR: implications of activat-ing mutations identified in FH

    • The CaR is a member of family 3 of the GPCR superfamily. Family 3 is characterized by a large extracellular amino-terminus consisting of two domains, a bilobed venus flytrap (VFT) domain and a cysteine-rich domain, a seven-transmembrane domain (7TM) typical … Continue reading

    Activating mutations of the calcium-sensing receptor in primary hypoparathyroidism: Familial hypoparathyroidism: genetic, clinical and diag-nostic features

    • While hypocalcemia and relative hypercalciuria are the hallmarks of FH caused by activating CaR mutation, the age of on set and severity of symptoms vary widely between different families and even within a family with the identical mutation. In some … Continue reading

    Activating mutations of the calcium-sensing receptor in primary hypoparathyroidism

    • The expression cloning of the bovine calcium-sensing receptor (CaR) just over a decade ago led immediately to studies showing that this novel G protein-coupled receptor (GPCR) is abundantly expressed in parathyroid and kidney where it mediates direct control by serum … Continue reading